The potential beneficial effects of inactivated Bifidobacterium Longum on the alleviation of muscle atrophy and physical fatigue in aged hospitalized and athletes using in vitro and in vivo models.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K15466
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 38050:Food sciences-related
• Research Institution: University of Tsukuba
• Principal Investigator: Ben Othman Mahmoud 筑波大学, 健幸イノベーション開発研究センター, 研究員 (40868337)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: anti-fatigue / muscles atrophy / treadmill / power strentgh / C2C12 cells

Outline of Final Research Achievements

In order to evaluate the anti-fatigue effect of inactivated Bifidobacterium longum (IBL) extract, some experiments were performed on mice. First of all, mice were exposed to running test using treadmill. Then, we investigate the effect of IBL on immobilization by applying the hindlimb test. The results showed a significant increase of the running distance of treated mice compared with non-treated mice. In addition, the results demonstrated a remarkable increase of power strength in treated groups. Moreover, muscles weight was improved in IBL-treated groups.

Free Research Field

muscles atrophy and anti-fatigue

Academic Significance and Societal Importance of the Research Achievements

our research showed that IBL can be used for anti-fatigue and muscles atrophy in mice. however, it can be used for human treatment. People who suffering from serious injuries and immobility period due to hospitalization, BL can be a relative treatment.