2021 Fiscal Year Annual Research Report
An approach to increase the gut-derived maternal immunoglobulin A (IgA) production using dietary tryptophan via aryl hydrocarbon receptor
| Project/Area Number |
20K15478
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| Research Institution | Tohoku University |
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Principal Investigator |
イスラム ジャヒドゥル 東北大学, 農学研究科, 特任助教 (20805569)
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | Immunoglobulin A / Mammary gland / Tryptophan / AHR / Plasma cells |
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| Outline of Annual Research Achievements |
Immunoglobulin A (IgA) has an important role as the cornerstone of defensive immunity. The mammary gland of the mother produces antibodies after childbirth. Plasma cells migrate from the intestinal tract and increase IgA in milk. However, most of the changes in the amount of intestinal IgA and its role during the perinatal period is still unknown. Therefore, this study for the first time investigated the intestinal IgA production and its role in strengthening immunity during the perinatal period through tryptophan (Trp) supplementation.
Feces of mice fed with 0.5% Trp-added basal feed and basal feed over time were collected and the IgA concentration in the feces was measured. Six weeks after the start of feeding, the large intestine was collected to address the number of plasma cells. In addition, using mice born 6 to 8 weeks after the start of feeding, feces and milk were collected to measure IgA concentration. The large intestine and mammary gland were collected in the second week of breastfeeding, to investigate the number of plasma cells. Fecal IgA levels increased significantly in the Trp group after 4 weeks of feeding bottom. However, there was no significant difference in the number of plasma cells in the large intestine 6 weeks after the start of feeding. Trp is thought to increase IgA production from individual plasma cells via aryl hydrocarbon receptor (AHR). Fecal IgA levels also increased significantly in the Trp group during early and late pregnancy. Trp is highly demanding, suggesting that Trp can enhance immunity in the intestinal tract.
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Research Products
(6 results)
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[Presentation] 難治性下痢症発症牛に対する糞便移植の有効性評価2022
Author(s)
Jahidul Islam, 谷水優江, 清水優, 五島可祥, 大谷夏輝, 大谷夏輝, 舘崎恵理子, 佐藤茉純, 牧野英司, 島田亘, 上田千世, 田中秀和, 野地智法
Organizer
日本無菌生物ノートバイオロジー学会
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