To Elucidate of the role of Lipid Metabolism in Arteriosclerosis Induced by Synthetic Sugar Intake

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K15481
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 38050:Food sciences-related
• Research Institution: Kobe University
• Principal Investigator: MORI KENTA 神戸大学, 医学部附属病院, 助教 (00813073)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 異性化糖 / コレステロール引き抜き能 / コレステロール取り込み脳 / HDL / 尿酸値

Outline of Final Research Achievements

The health effects of fruit-derived fructose (Fru), industrially produced isomerized sugar (HFCS), and zero-calorie sweetener (ASP) compared to glucose (Glu), a normal sugar, were examined in a loading test in clinical cases. The results of the HDL function before and after the intervention showed a strong decrease in function in the Fru group, followed by the HFCS group, and then the Glu group. Furthermore, it was found that the function of HDL's anti-atherosclerotic effect changed depending on the type of fatty acid constituting HDL, and that ω-3 fatty acids improved the anti-atherosclerotic effect of HDL. In addition, there was a significant relationship between the rate of change in the anti-atherosclerotic effect of HDL and uric acid levels, suggesting a mechanism in which HDL and uric acid metabolizing enzymes are related.

Free Research Field

食品科学関連

Academic Significance and Societal Importance of the Research Achievements

糖の過剰摂取が糖代謝異常などの健康被害を及ぼすことから、摂取カロリー制限のため、甘味が強い果糖を含む合成糖の使用が増加した。その反面、合成糖の健康被害の可能性が報告されているが、動脈硬化への影響やその機序は依然不明な点が多い。果糖を含む合成糖が動脈硬化発症・進展に及ぼす影響を明らかにし、その機序を解明するため、また予防策の検討を含めて研究を行った。その結果、日常摂取する糖のうち、果糖を含む合成糖が動脈硬化発症・進展に及ぼす影響が明らかになった。そして合成糖による健康被害を予防するためには、ω-3脂肪酸などの栄養素の摂取が有効である可能性が示唆された。