2023 Fiscal Year Final Research Report
Influence of renal lipid metabolism abnormalities on urinary lipid profiles in dogs and cats with renal disease
| Project/Area Number |
20K15679
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 42020:Veterinary medical science-related
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 尿中不飽和脂肪酸 / SREBP1 / 慢性腎臓病 / 猫 / 犬 |
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| Outline of Final Research Achievements |
We comprehensively analyzed the fatty acid content of the kidneys of cats with and without chronic kidney disease (CKD) as material and further evaluated the expression of transcription factors involved in fatty acid metabolism; we found a trend toward higher content of some fatty acid species and expression of SREBP1, which is involved in promoting unsaturated fatty acid synthesis, in the kidneys of CKD cases. These results predicted fatty acid accumulation and unsaturation in the kidneys of cats with CKD. Next, we comprehensively analyzed urinary fatty acids in CKD and non-CKD cats and dogs. In cats, the urine of CKD cases contained high levels of unsaturated fatty acids such as C16:1, C18:1, and C18:2, while a similar trend was observed in dogs. These results suggest that the excretion of some unsaturated fatty acids in urine may be increased in cats and dogs with renal diseases such as CKD.
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| Free Research Field |
獣医内科学
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| Academic Significance and Societal Importance of the Research Achievements |
CKDに罹患した猫では一部の脂肪酸種が腎尿細管領域に蓄積し、それらに由来する不飽和脂肪酸の尿への排泄が増加すると考えられ、犬でも腎疾患の病態によっては同様の傾向を示すと考えられた。SREBP1は組織における脂肪酸の合成を促進するとともに、飽和脂肪酸を組織傷害性のない不飽和脂肪酸に変化させる組織の保護機能を有している。そのため腎疾患により腎臓組織が傷害されると尿への不飽和脂肪酸の排泄が増加する可能性が考えられた。尿中における一部の中鎖不飽和脂肪酸については、CKDをはじめとする腎疾患の臨床マーカーとしての利用が期待できる。
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