2022 Fiscal Year Final Research Report
Identification of non-coding driver mutations
Project/Area Number |
20K15780
|
Research Category |
Grant-in-Aid for Early-Career Scientists
|
Allocation Type | Multi-year Fund |
Review Section |
Basic Section 43060:System genome science-related
|
Research Institution | Kyushu University |
Principal Investigator |
Nakashima Chie (菊竹) 九州大学, 生体防御医学研究所, 助教 (30843833)
|
Project Period (FY) |
2020-04-01 – 2023-03-31
|
Keywords | バイオインフォマティクス / がんゲノム / 生物統計 |
Outline of Final Research Achievements |
In this study, to reveal the impact of highly mutated open chromatin regions on cancer, we investigated the association between mutations in open chromatin regions and their possible functions. In some cancer types, the proportion of promoter or enhancer chromatin state in open chromatin regions with a high number of mutations was significantly higher than that in the regions with a low number of mutations. The possible target genes of open chromatin regions with a high number of mutations were more strongly associated with cancer than those of other open chromatin regions. Moreover, a high number of mutations in open chromatin regions was significantly associated with a poor prognosis in some cancer types. These results suggest that highly mutated open chromatin regions play an important role in cancer pathogenesis and can be effectively used to predict patient prognosis.
Keywords: TCGA; bioinformatics; cancer genetics; genomics; medical genetics.
|
Free Research Field |
バイオインフォマティクス
|
Academic Significance and Societal Importance of the Research Achievements |
オープンクロマチンは遺伝子の発現調節において重要な役割を持つ。この研究では、多くの変異を持つオープンクロマチン領域ががんに対してどのような影響を及ぼすかについて解析を行った。解析の結果、変異の多いオープンクロマチン領域の標的遺伝子は、がんと強く関連していた。さらに、オープンクロマチン領域の変異数が多い患者は予後が不良であることも分かった。
|