2021 Fiscal Year Final Research Report
Understanding the role of TCP11 and TCP11L3 in hyperactivation
| Project/Area Number |
20K15804
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 44020:Developmental biology-related
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| Research Institution | Osaka University |
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Principal Investigator |
Castaneda Julio 大阪大学, 微生物病研究所, 特任助教(常勤) (00791659)
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | sperm / sperm motility / infertility / Tcp11 / cAMP signaling |
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| Outline of Final Research Achievements |
This research identified one gene (Tcp11) that is important for sperm motility, and a related gene (Tcp11 Like 3) that is not necessary for sperm movement. When we remove the Tcp11 gene in mice, sperm have decreased movement and the male mice are infertile. Humans also have the Tcp11 gene, and this research suggests that Tcp11 may also be important for sperm motility in men.
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| Free Research Field |
reproduction
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| Academic Significance and Societal Importance of the Research Achievements |
This research identified Tcp11 as important for sperm motility. The research suggests that Tcp11 is functioning through the cAMP signaling pathway. The societal benefits is in human reproduction. In infertile men whose sperm are immotile, we think Tcp11 might be the cause of this defect.
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