2022 Fiscal Year Research-status Report
Feeding regulation in jellyfish
| Project/Area Number |
20K15838
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | Jellyfish / Appetite / Evolution / Feeding / Neuropeptide |
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| Outline of Annual Research Achievements |
The main research achievement has been the publication of a research article entitled ‘On the origin of appetite: GLWamide in jellyfish represents an ancestral satiety neuropeptide’ in the international journal PNAS. This required additional experiments and analyses, as requested by the reviewers, including: (a) further characterization of the behavioral effects of GLWamide; (b) anatomical characterization of peptide-expressing neurons in Drosophila and Cladonema and (c) bioinformatic analysis of Cladonema G protein-coupled receptors. Following publication, I also built on the results by characterizing the effect of satiety in the jellyfish Cladonema in greater detail.
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
Following further delays with the initial review process, I had to submit our article to a new journal. New reviewers were assigned to evaluate the work, which meant new experiments that needed to be carried out before acceptance.
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| Strategy for Future Research Activity |
Now that the findings regarding the role of GLWamide in jellyfish feeding regulation have been made public, I plan to turn my attention to other peptides that also play a role in this behavior. Specifically, I plan to pursue the following objectives: (a) characterize in detail the multiple effects of satiety on jellyfish feeding, expanding the previous work; (b) identify the nature of the satiety signal and the pathways necessary to convey it; (c) investigate the behavioral mechanisms by which the other identified peptides regulate feeding; (d) raise antibodies against these peptides to characterize their expression and (e) identify neurons driving satiety using an activity reporter.
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| Causes of Carryover |
Because of delays in the review process, some of the initially planned experiments had to be postponed to the next fiscal year.
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[Journal Article] On the origin of appetite: GLWamide in jellyfish represents an ancestral satiety neuropeptide2023
Author(s)
Thoma V, Sakai S, Nagata K, Ishii Y, Maruyama S, Abe A, Kondo S, Kawata M, Hamada S, Deguchi R, Tanimoto H.
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Journal Title
Proceedings of the National Academy of Sciences of the United States of America
Volume: 120
Pages: e2221493120
DOI
Int'l Joint Research
