2022 Fiscal Year Final Research Report
Elucidation of the developmental system contributing to the conservation of blastomere fate in spiralian development
| Project/Area Number |
20K15849
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 45020:Evolutionary biology-related
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | らせん卵割型発生 / 初期発生 / 進化発生学 / 転写因子 / 軟体動物 |
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| Outline of Final Research Achievements |
To elucidate the molecular developmental system responsible for the conservation of blastomere fate in spiralian development, we performed comparative transcriptome analysis of mollusks, annelids, and platyhelminthes, and functional analysis of transcription factors which are expressed in early cleavage stage. Among mollusks and annelids, the repertoire and expression pattern of transcription factors expressed zygotically during cleavage were not highly conserved. Also, in flatworms, we could not find transcription factors that are expressed in specific blastomeres at cleavage stage in common with other animal phyla. Furthermore, we identified novel transcription factors involved in blastomere fate specification in mollusks, but their presence/expression was not always common among the three phyla. These findings imply the diversification of blastomere fate specification mechanisms within spiralian animals.
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| Free Research Field |
進化発生学
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| Academic Significance and Societal Importance of the Research Achievements |
動物の高次分類は中学校/高校の生物の教科者でも取り扱われる社会的関心の高いトピックであるが、動物の高次分類群を規定する形質がどのように成立し、なぜ進化の過程で変化しにくいのかということは、当該分野の領域内においても議論が続いている。本研究課題では、らせん卵割動物を規定する保存性の高い初期発生を制御する分子メカニズムの解析を行い、それらの発生システムのらせん卵割動物内での意外な多様性を明らかにした。これらの知見は、動物の高次分類群を規定する形質の進化機構についての理解を前進させるものである。
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