2023 Fiscal Year Final Research Report
New evolutionary model based on evolutionary developmental studies of hatching gland cells
| Project/Area Number |
20K15850
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 45020:Evolutionary biology-related
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 魚類 / 両生類 / 卵保護 / 繁殖戦略 / 孵化 / 卵膜 |
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| Outline of Final Research Achievements |
In this study, we focused on the evolution of hatching enzymes, which are essential for the hatching of oviparous vertebrates, and their producing cells, hatching gland cells. Our results comprehensively elucidate the molecular evolution of the astacin family, including hatching enzymes, across vertebrates. Additionally, we identified the genes associated with egg protection in fish and elucidated their evolutionary patterns, thereby linking the evolution of fish reproductive strategies and ecological adaptation. Furthermore, to investigate the differentiation cascade of hatching gland cells, we successfully generated and established multiple mutant zebrafish lines.
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| Free Research Field |
進化生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では孵化酵素を始めとした、孵化に関連する遺伝子の網羅的な分子進化パターンを明らかにしている。特に222魚種の全ゲノム配列を用いた網羅的な解析からあきらかになった卵保護との関連が強く示唆される遺伝子の偽遺伝子化は、水産業への応用も見込めるだけでなく、深海魚などの繁殖方法が未同定の種における非侵襲的な遺伝子マーカーとしても応用展開が見込めるものである。このように、本研究成果は脊椎動物の繁殖生態について重要な知見をもたらすだけでなく、その社会的意義も大きいものである。
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