Physiological diversity and interrelationships between osteoporosis and sarcopenia in elderly Japanese

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K15888
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 45060:Applied anthropology-related
• Research Institution: Nagasaki University
• Principal Investigator: Mizukami Satoshi 長崎大学, 医歯薬学総合研究科(医学系), 助教 (20814502)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 骨粗鬆症 / 海綿骨骨密度 / 身体機能 / FRT

Outline of Final Research Achievements

The participants included 80 women individuals aged 40 years and older.Sixty-five (81.3%) had low trabecular bone mineral density and 60 (75.0%) had low cortical bone thickness. The group with low trabecular bone mineral density was significantly older, had significantly longer chair stand times, significantly shorter FRT, and significantly higher percentages of patients with comorbidities. Logistic regression analysis with low trabecular bone mineral density as the dependent variable showed that short FRT was significantly associated with low trabecular bone mineral density, with an odds ratio for FRT of 1.14 (95% confidence interval: 1.01-1.27), even after adjustment for age, BMI, alcohol consumption, and comorbidities.
In middle-aged and older women, shorter FRT was significantly associated with lower trabecular bone mineral density.

Free Research Field

公衆衛生学

Academic Significance and Societal Importance of the Research Achievements

地域在住日本人中年女性において、バランス能力の指標であるFRTが短いことは海綿骨骨密度低下の有意な決定因子であった。しかし、皮質骨厚とは有意な関連がみられなかった。閉経を目前とした中年女性の骨健康に関して、バランス能力の維持向上が骨粗鬆症や脆弱性骨折の予防因子となることが示唆された。
生理人類学の観点からバランス能力や骨量の変動は環境や生活状況の変化に対する人類の適応能を理解するうえで役立つと考える。