2021 Fiscal Year Final Research Report
Revealing the function of offline LTP in memory consolidation
Project/Area Number |
20K15901
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 46010:Neuroscience-general-related
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Research Institution | Kyoto University |
Principal Investigator |
Goto Akihiro 京都大学, 医学研究科, 助教 (10741332)
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Project Period (FY) |
2020-04-01 – 2022-03-31
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Keywords | 記憶 / LTP / 固定化 |
Outline of Final Research Achievements |
We investigated whether LTP (a cellular-level phenomenon of memory) is induced not only immediately after learning but also in the offline state afterward, and if so, how it contributes to memory formation. To this end, we used a technique in which LTP is canceled by light. If memory is erased by light irradiation, then LTP is induced in that time frame. We found that offline LTP was induced in the hippocampus on the same day as after learning and in the anterior cingulate cortex during sleep on the following day, indicating that offline LTP contributes to memory consolidation, which is the goal of this project.
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Free Research Field |
神経科学
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Academic Significance and Societal Importance of the Research Achievements |
本研究により、記憶が長期的に保存されるための細胞レベルでのメカニズムを解明することができた。学習後に睡眠をとることで、学習当日は海馬でoffline LTPが誘導され、その翌日には前帯状皮質でoffline LTPが誘導され、それにより記憶が長期的に保存されることを明らかにした。記憶を長期的に保存するという社会的意義の高い生命現象のメカニズム解明解明したことで、今後臨床なども含めた社会還元につながる研究成果を得ることができた。
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