2022 Fiscal Year Annual Research Report
Measurement of Chromatin Architecture, and its Function in Regulating Neuronal Activity
| Project/Area Number |
20K15909
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
徐 方可 国立研究開発法人理化学研究所, 脳神経科学研究センター, 基礎科学特別研究員 (60867216)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | neuronal activity / gene expression / chromatin organization / transcription factor |
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| Outline of Annual Research Achievements |
Activation of somatic sensory neurons commonly leads to fast behavioral responses, while what longer-lasting influences could be left on the overall fitness of the animals is not yet clear. We are interested in investigating the gene expression and chromatin organization changes upon neuronal activations.
Utilizing a sub-type of somatic sensory neurons (C4da) in the fly larvae, our current data suggested that while C4das are constantly activated through TrpA1, many other signaling-related genes are down-regulated. Furthermore, one clearly up-regulated gene has been found in the NuRD complex, suggesting that the gene expression reductions could be controlled from the chromatin structure level. We will further confirm and investigate those changes with ATAC-seq or ChIP-seq using C4da neurons.
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Research Products
(1 results)
