2023 Fiscal Year Annual Research Report
Evolution of cerebro-cerebellar system investigated using resting-state functional connectivity in macaque and human
| Project/Area Number |
20K15945
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
アウティオ ヨーナス 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 (40755485)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | Functional imaging / Evolution / Comparative neuroscience / Cerebellum |
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| Outline of Annual Research Achievements |
In this research project, my primary objective was to compare the functional organization of the macaque and human cerebellar cortices. For macaque monkeys, data acquisition was successfully completed for high-resolution structural images by 2021 and for functional imaging by 2022. The comparison of the functional organization of the cerebellum revealed significant species differences, particularly in working memory, higher-visual, and default-mode networks. Interestingly, the human cerebro-cerebellar language network in macaque monkeys exhibit functional connectivity only auditory areas suggesting it is an early pre-language circuit. Unfortunately, the project experienced significant delays due to a failure of the 2023 Kobe RIKEN cloud server, where all the analyzed data was stored. This has caused substantial setbacks to the project. Nonetheless, manuscript is currently in preparation.
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