2022 Fiscal Year Final Research Report
Study on the mechanism of SIRT1 activation by cinnamoyl derivatives in beige adipogenesis
| Project/Area Number |
20K16018
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 47040:Pharmacology-related
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| Research Institution | Matsuyama University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | シンナモイル誘導体 / ベージュ脂肪細胞 / SIRT1 / 肥満 |
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| Outline of Final Research Achievements |
Coffee consumption has been shown to reduce the risk of developing type 2 diabetes mellitus (T2DM) in humans; however, the exact mechanism is not completely understood. Here, we demonstrate that N-caffeoyltryptophan (NCT), an ingredient of coffee, enhances adipogenic differentiation and promotes glucose uptake into adipocytes. NCT might contribute to the reduction in postprandial glycemia and a subsequent reduction in onset risk for T2DM.
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| Free Research Field |
薬理学
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| Academic Significance and Societal Importance of the Research Achievements |
飽食時代を迎え，肥満者・２型糖尿病患者の増加が国際的に問題視されている．近年，習慣的なコーヒー摂取による2型糖尿病発症リスク低減効果が多く報告されており，健康増進や創薬の観点から，多くの研究者の注目を集めている．しかし，この効果を発揮する主たるコーヒー成分やメカニズムについては不明な点が多く，コーヒー摂取による抗肥満・2型糖尿病予防効果の“真”のメカニズムの解明が望まれている．
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