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2021 Fiscal Year Final Research Report

Function analysis of a polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood

Research Project

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Project/Area Number 20K16025
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 47050:Environmental and natural pharmaceutical resources-related
Research InstitutionUniversity of Toyama

Principal Investigator

Takeshi Kodama  富山大学, 学術研究部薬学・和漢系, 助教 (40710207)

Project Period (FY) 2020-04-01 – 2022-03-31
Keywords沈香 / 生合成 / ポリケタイド合成酵素 / X線結晶構造解析
Outline of Final Research Achievements

2-(2-Phenylethyl)chromones (PECs) are the principal constituents contributing to the distinctive fragrance of agarwood. In this work, we describe a type III polyketide synthase (PECPS) identified from Aquilaria sinensis. We demonstrate that the scaffold of diarylpentanoid is the common precursor of PECs, and PECPS plays a crucial role in PECs biosynthesis. Crystal structure analyses of PECPS employs a one-pot formation mechanism for the formation of the diarylpentanoid scaffold.

Free Research Field

天然物化学

Academic Significance and Societal Importance of the Research Achievements

2-(2-フェニルエチル)クロモン類(PECs)の生合成に関与するⅢ型ポリケタイド合成酵素であるPECPSの機能を明らかにしたことで,薬学的に有用なPECsについて代謝工学を利用して大量に合成できる可能性を示しただけでなく,沈香がどのように形成されるかをさらに探求するための知見を得ることで,密栽が行われている沈香の作成に利用される基原植物の生態系を守ることにもつながると期待される。

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Published: 2023-01-30  

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