Elucidation of the response mechanism of sublingual immunotherapy(SLIT) for Japanese Cedar Pollinosis and establishment of a method for predicting response

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16054
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 47060:Clinical pharmacy-related
• Research Institution: Teikyo Heisei University
• Principal Investigator: KURISAKA Chisato 帝京平成大学, 薬学部, 助教 (00846785)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 舌下免疫療法 / スギ花粉症 / EXiLE法

Outline of Final Research Achievements

The aim of this study was to develop a method for predicting response to sublingual immunotherapy (SLIT) with cedar pollen and to elucidate the mechanism of SLIT.
Patients with elevated cedar pollen-specific IgG4 levels and no IgE fluctuations showed an increase in EC50 after treatment with the EXiLE method without washing, while patients with decreased IgE levels showed an increase in EC50 both with and without washing. No correlation was observed between IgE fluctuations and the EXiLE method (EC50), suggesting that an increase in EC50 is not a good indicator of an increase in neutralizing antibodies. However, it was suggested that EC50 may increase without washing regardless of IgE levels.

Free Research Field

アレルギー

Academic Significance and Societal Importance of the Research Achievements

花粉症の根治可能な治療法としてSLITが注目されているが、治療早期においてSLITの効果が判断できる試験法またはバイオマーカーが求められている。本研究により、洗浄なしEXiLE法を実施することで治療前後の特異的IgEの変動に関わらず、治療後でEC50が有意に増加する可能性が示唆された。本研究の結果から洗浄なしEXiLE法による解析を行うことで、奏効性予測法の確立やSLIT成立機序解明への一助になると考えられた。