Population pharmacokinetic analysis of vancomycin based on standardized estimated glomerular filtration rate (eGFR).

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16055
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 47060:Clinical pharmacy-related
• Research Institution: Kitasato University
• Principal Investigator: KOBAYASHI MASAHIRO 北里大学, 薬学部, 准教授 (90815359)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: バンコマイシン / 母集団薬物動態解析 / 推算糸球体濾過量 / 非線形混合効果モデル

Outline of Final Research Achievements

We investigated a population pharmacokinetic analysis of vancomycin using estimated standard glomerular filtration rate (eGFR). Population pharmacokinetic parameters Vdvcm (L) = 1.09 * WT(kg), CLvcm (L/h) = 1.09 + 0.0415 * standard eGFR (mL/min/1.73m^2) were obtained using a nonlinear mixed-effects model. Population pharmacokinetic parameters obtained by a similar approach, using estimated creatinine clearance, showed better model eligibility and external validity. At this time, we conclude that population pharmacokinetic parameters using eGFR as a covariate may be useful for vancomycin dosing design, but cannot be a better covariate than Ccr.

Free Research Field

薬物動態学

Academic Significance and Societal Importance of the Research Achievements

代表的な腎機能の定量的指標として推算糸球体濾過量(eGFR)と推定クレアチニンクリアランス(Ccr)が普及し、薬物投与設計における使用方法が混在している。バンコマイシンを対象とした本研究結果より、精密な投与設計や血中薬物濃度の推定精度を追求する必要性の高い場面では指標としてCcrの方が優れており、そうでない場面ではeGFRで代用できる可能性を示した。