Reverse translational research based on a novel pharmacokinetic control theory for immunosuppressive drugs

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16080
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 47060:Clinical pharmacy-related
• Research Institution: University of Miyazaki
• Principal Investigator: Yoshikawa Naoki 宮崎大学, 医学部, 薬剤部長補佐 (60866383)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 免疫抑制薬 / タクロリムス / 赤血球 / FKBP

Outline of Final Research Achievements

In this study, we attempted to clarify the role of FK506 binding protein (FKBP) in the red blood cells (RBCs) distribution of tacrolimus in vivo by elucidating the intracellular distribution mechanism of tacrolimus based on its interaction with FKBP.
It was suggested that the capture of tacrolimus by FKBP12 prior to its contact with RBCs decreases the RBCs distribution of tacrolimus. In addition, the contribution of intracellular FKBP12 molecules was found to be extremely significant in the intracellular distribution of tacrolimus.

Free Research Field

医療薬学

Academic Significance and Societal Importance of the Research Achievements

本研究において、生体内でのタクロリムスの赤血球移行におけるFKBPの役割を一部明らかにした。本成果は、これまで不明であったタクロリムスの赤血球移行機序において、FKBPが果たす役割とその寄与率の解明に迫るものと考える。本研究成果はタクロリムスの新たな体内動態制御理論の構築につながる極めて有益な知見である。