Construction of nasal vaccination system based on co-delivery of antigens and immunostimulants by the polymers bearing cell-penetrating peptides.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16097
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 47060:Clinical pharmacy-related
• Research Institution: Setsunan University
• Principal Investigator: Ukawa Masami 摂南大学, 薬学部, 助教 (50735511)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 粘膜ワクチン

Outline of Final Research Achievements

Our research aimed to develop the mucosal vaccine which has superior therapeutic effect via the collaboration of ligands to Toll-like receptor (TLR) as immune stimulant and oligoarginine-linked polymer designed in our laboratory. The synergic improvement of adjuvancy was not observed by the collaboration of oligoarginine-linked polymer and TLR ligands. It was suggested to be the bottleneck for the concept that the addition of TLR ligands would inhibit the delivery of antigen into dendritic cells by oligoarginine-linked polymers.

Free Research Field

製剤学

Academic Significance and Societal Importance of the Research Achievements

経粘膜投与可能な薬剤は点鼻などによって投与が可能であり、患者の負担を減らすことができる。一方、注射型のものよりも活性が低いため、生ワクチン製剤を除き、臨床応用に至っていない。本研究では生ワクチンのような生きたウイルスを使用する必要がなく、人工的なポリマーを用いているため、効果が高い経粘膜ワクチンが作製できれば、安全性の面で優位性のあるワクチンとなると考えられる。