2022 Fiscal Year Annual Research Report
Clarification of protective functions of Huntingtin-associated protein 1 against autonomic and motoneuron degeneration using genetically-engineered mice
| Project/Area Number |
20K16108
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| Research Institution | Yamaguchi University |
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Principal Investigator |
イスラム エムディノビウル 山口大学, 大学院医学系研究科, 講師 (80759671)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | HAP1 / STB / Enteric neurons / Autonomic neurons |
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| Outline of Annual Research Achievements |
In our previous study, we clarified the expression of STB/HAP1 in the forebrain and in the spinal cord. We also clarified the STB/HAP1 expression in the Myenteric plexus of enteric neurons. In the last year of this project, we were the first to clarify the characterization of HAP1-immunoreactive cells in reference to secretomotor and vasodilator submucosal neurons. Our current results reveal that HAP1 is expressed in all the secretomotor and vasodilator neurons. This study might reflect the involvement of HAP1 in the modulation of the secretomotor and vasodilator functions of submucosal neurons. Our present results lay an essential foundation for future studies that seek to clarify the physiological and pathological roles of HAP1 in the submucosal plexus of ENS.
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