Analysis on the pathogenesis of proton pump inhibitor-associated fundic gland polyps and dysplasia

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16174
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: Oita University
• Principal Investigator: Masahide Fukuda 大分大学, 医学部, 医員 (80854299)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 胃底腺ポリープ / プロトンポンプ阻害薬 / dysplasia

Outline of Final Research Achievements

Dysplasia with fundic gland polyps are gatrtic fovelar-type neoplasm.
An original　cancer gene panel for gastric cancer was designed and genetic analysis was performed on 21 lesions in 19 cases of gastric foveolar-type neoplasm. As a result, gastric foveolar-type neoplasm did not show any characteristic gene mutations as reported in gastric cancer.　21 lesions in 12 cases of fundic gland polyps set as the control group, CTNNB1 mutations were observed in 9 lesions, and APC gene mutations were observed in 2 lesions.

Free Research Field

消化管病理

Academic Significance and Societal Importance of the Research Achievements

胃腺窩上皮型腫瘍には既知のような胃がんで認められる遺伝子変異は認められなかった。また、胃底腺ポリープとも別の病変である可能性が考えられた。微小な検体から遺伝子を抽出し、遺伝子解析を行うことが可能であることが分かった。