2023 Fiscal Year Final Research Report
Mechanism of exacerbation of dementia based on excessive intraventricular transport of lactate via transporters in choroid plexus epithelial cells.
| Project/Area Number |
20K16193
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 49020:Human pathology-related
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 認知症 / 乳酸 / 脈絡叢 |
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| Outline of Final Research Achievements |
It is known that dementia is common among diabetic patients. Based on the assumption that lactic acid is the cause, I focused on the choroid plexus, which produces spinal fluid that feeds the brain, and examined how it moves. I identified transporters in the choroid plexus that transport lactate and receptors that utilize lactate, and reported this in a paper.
I had planned to conduct lactate excess experiments in animals, but since the distribution of lactate transporters was very different between humans and experimental animals, we changed the experimental plan and made comparisons with other organs in humans. Specifically, the placenta and kidneys.
I plan to elucidate the role of lactate in the brain by analyzing the brain, placenta, and kidney, which are similar tissues in the sense that they exchange water and substances in and out of blood vessels.
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| Free Research Field |
認知症
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| Academic Significance and Societal Importance of the Research Achievements |
ヒト脳において脊髄液を産生する脈絡叢という組織で、乳酸を運んだり利用するための構造があることが確認され、論文として報告しました。現在この乳酸の詳しい働きは不明です。
脈絡叢という組織は記憶を司る海馬という組織に隣接しており、その機能へ影響する可能性があります。
乳酸と認知症についてこれからさらなる検討を行い、治療や予防につながる報告ができればと思います。
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