2021 Fiscal Year Final Research Report
Development of a new therapeutic method targeting nucleic acid recognizing TLRs for ANCA -associated vasculitis
| Project/Area Number |
20K16227
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 49030:Experimental pathology-related
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| Research Institution | Musashino University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | ANCA関連血管炎 / 自己免疫疾患 / 核酸認識Toll様受容体 |
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| Outline of Final Research Achievements |
ANCA-associated vasculitis (AAV) is a disease characterized by the detection of antibodies against neutrophil cytoplasmic antigens (ANCA, autoantibodies) and inflammation of multiple organs and tissues such as glomerulonephritis. We have recently reported that Toll-like receptors (TLRs) that recognize DNA and RNA are involved in autoimmune kidney nephritis. Therefore we analyzed the significance of these TLR responses in an AAV mouse model(SCG/ThpNkc mice) and found that TLR7 knockout had a partial suppressive effect on the pathogenesis. These results may contribute to the elucidation of new pathogenesis-forming mechanisms and the development of therapeutic agents.
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| Free Research Field |
免疫学
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| Academic Significance and Societal Importance of the Research Achievements |
ANCA関連血管炎は、難病指定された根治の難しい疾患である。治療法は免疫抑制剤やステロイド製剤の投与であり、副作用の少ない治療法の開発が求められている。またこれらの薬に抵抗を示す患者もいる。本研究では、AAVモデルマウスを用いて、TLR7の病態への関与を検証した。我々は、独自に樹立した抗TLR7阻害抗体やTLR7KOマウスを用いて解析したところ、部分的にAAVの病態を抑制する結果を得た。これらの結果は、新たな病態形成メカニズムの解明と治療薬の開発に貢献すると考えられる。
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