2020 Fiscal Year Research-status Report

Characterization of unstudied RND-type multidrug efflux pumps from pathogenic microorganisms

Research Project

Project/Area Number	20K16242
Research Institution	Osaka University
Principal Investigator	ZWAMA MARTIJN 大阪大学, 産業科学研究所, 特任助教(常勤) (40827052)
Project Period (FY)	2020-04-01 – 2023-03-31
Keywords	RND / Transporter / Multidrug Resistance / MDR / AcrB / Evolution
Outline of Annual Research Achievements	Cloned and studied efflux pumps from multiple bacteria, now still being researched. Interesting results have been come to light regarding the function of RND-type multidrug efflux pumps, their evolution, their conservation, and their function.
Current Status of Research Progress	Current Status of Research Progress 1: Research has progressed more than it was originally planned. Reason More pumps were active than hoped for, and plenty of data has been produced, especially taking into account the COVID-19 pandemic which caused slight delays.
Strategy for Future Research Activity	Continue with the research as planned and perform experiments based on the positive procedures and results obtain in FY2020.
Causes of Carryover	Delays due to the pandemic, experiments will be carried out from FY2020 and FY2021 onwards, products and services (such as DNA and peptide synthesis) will be requested from FY2021 onwards.

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