Analysis of the mechanism of gastric inflammation induced by small RNAs of H. pylori.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16244
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49050:Bacteriology-related
• Research Institution: Nagoya University (2021-2022); Osaka University (2020)
• Principal Investigator: Kinoshita-Daitoku Ryo 名古屋大学, 医学系研究科, 特任助教 (50846566)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: ピロリ菌 / small RNA

Outline of Final Research Achievements

Helicobacter pylori (H. pylori) infection is known to be involved in the development of gastrointestinal diseases such as gastritis, gastric ulcer, gastric cancer, and MALT lymphoma. In this study, we found that sRNA-X and sRNA-Z possessed by H. pylori are involved in the development of gastritis. Furthermore, we found that the expression levels of sRNA-X correlated with clinical findings based on the results of experiments using clinical isolates of H. pylori. These results indicate that the pathogenic sRNAs possessed by H. pylori contribute to gastritis caused by H. pylori.

Free Research Field

細菌学

Academic Significance and Societal Importance of the Research Achievements

ピロリ菌は世界人口の約半数が感染している大規模感染症であり、胃炎や胃がんなどの消化器疾患を引き起こすことが知られているが、胃炎発症メカニズムは不明な点が多い。しかし本研究を通じて、ピロリ菌が保有するsmall RNAが胃炎発症メカニズムに関与している可能性が示唆された。本研究で得られた新知見は、他の細菌感染症解析の道を拓くほか、創薬・ワクチン開発へとつながることが期待される。