2023 Fiscal Year Annual Research Report
Single-cell transcriptomic and epigenomic analysis of young and elder mouse gastric mucosa infected by Helicobacter pylori
| Project/Area Number |
20K16347
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| Research Institution | Hoshi University |
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Principal Investigator |
Liu Yuyu 星薬科大学, 先端生命科学研究所, 特任助教 (10870462)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | Gastric stem cell |
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| Outline of Annual Research Achievements |
This year, we added single-cell ATAC-seq data of 50-week-old mice and merged with previous data of 3-week-old and 20-week-old mice. Then, we analyzed the chromatin accessibility regions that are wholly close in 3-week-old stem cells but open in a small amount of stem cells in adult and aged mice. We considered these regions as age-associated detrimental chromatin regions that should remain close, otherwise causing pathogenic risks. On the contrary, we also picked up chromatin regions that are open in a small proportion of stem cells in 3-week-old mice but close wholly in adult and aged mice. These regions reflect a diversity in 3-week-old stem cells, possibly representing the epigenetic plasticity in youth.
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