Analysis of the anti-tumor immune effects of carboni-ion radiotherapy on lung cancer

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16405
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50020:Tumor diagnostics and therapeutics-related
• Research Institution: Gunma University
• Principal Investigator: Kubo Nobuteru 群馬大学, 大学院医学系研究科, 講師 (30727813)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 肺癌 / 重粒子 / 免疫 / リンパ球

Outline of Final Research Achievements

Blood tests were performed before treatment, immediately after treatment, and one month after treatment in cases treated with carbon-ion radiotherapy for stage I non-small cell lung cancer. The original plan was to examine 20 cases, but due to budget constraints, only 6 cases were included in the study. The samples are currently being stored in liquid nitrogen and will be analyzed together with other samples. comparing the clinical outcomes and lymphocyte status of the treated patients, the impact of immune status changes with heavy ion therapy on clinical outcomes will be analyzed. This study is preliminary, and validation study will be conducted based on the results of this study.

Free Research Field

腫瘍放射線学

Academic Significance and Societal Importance of the Research Achievements

現在、多くの癌において免疫との関係が注目されている。免疫を調べるというのは様々な研究所法があるが、今回はリンパ球を用いている。治療前のリンパ球を調べることにより予後予測をすることができれば、個別により最適な治療手段を検討することが可能となる。また予後不良群においても、免疫状態の変化などから併用する免疫療法などを検討することができ、予後改善に寄与できる可能性がある。