Analysis of the mechanism of cancer metastasis by synuclein-gamma

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16412
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50020:Tumor diagnostics and therapeutics-related
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Tani Soichiro 滋賀医科大学, 医学部, 助教 (40721022)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: Synuclein-γ

Outline of Final Research Achievements

Synuclein-γ, a neurofilament, was discovered in 1998 as a breast cancer-specific gene, and the expression of synuclein-γ has been reported as a prognostic factor in various cancers. In contrast, the molecular physiological mechanism of synuclein-gamma in distant metastasis of colorectal cancer is not clear. Synuclein-gamma is a nerve fiber, and staining conditions were examined using paraffin sections. In the study using clinical specimens, T-cell infiltration was low in synuclein-gamma-positive tumors, suggesting that it may be involved in immune responses.

Free Research Field

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Academic Significance and Societal Importance of the Research Achievements

大腸癌は、2017年悪性疾患罹患数が男女合わせて1位であり、対策が必要な疾患の一つである。大腸癌において遺伝子変異の重要性などが明らかになっているがSynuclein-γに関しては未だ十分ではない。Synuclein-γは神経繊維の一つの因子であり、がん微小環境におけるSynuclein-γの重要性を解明することで癌の治療やバイオマ ーカーの開発につながる可能性がある。