2021 Fiscal Year Final Research Report
Establishment of Global Gold Standard about radiotherapy adaptation criteria in patients with lung cancer using pulmonary quantification by Xenon CT
| Project/Area Number |
20K16442
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 50020:Tumor diagnostics and therapeutics-related
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | 肺定量評価 / 放射線治療 |
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| Outline of Final Research Achievements |
We have extracted cases of stereotactic irradiation of the lungs in the past, and analyzed how much emphysema and how normal lungs are damaged at a certain dose, resulting in extreme respiratory depression or introducing home oxygen therapy.
The following images were obtained using the treatment planning assistance software. A) Lung field B) Area of emphysematous changes visualized using CT values C) Area irradiated by each dose of 30 Gy, 20 Gy, 5 Gy D) B is subtracted from A and defined as normal lung. And then each dose range of C is subtracted. This was defined as the final normal lung. We consider this a new indicator and are submitting a paper. Respiratory function decline was observed with significant differences in both cases.
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| Free Research Field |
放射線腫瘍学
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| Academic Significance and Societal Importance of the Research Achievements |
今研究は肺障害と放射線治療の関連性の指標を見つけ出す研究であり、対象治療患者が将来在宅酸素導入になるかどうかを予測可能とする研究である。よって、この指標をうまく使うことで、患者に正確な予測事象を伝えることができ、よりよい放射線治療を行うことにつながると考えられる
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