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2021 Fiscal Year Research-status Report

Identification of biomarkers for precision medicine in patients with clear cell renal cell carcinoma

Research Project

Project/Area Number 20K16457
Research InstitutionKansai Medical University

Principal Investigator

大杉 治之  関西医科大学, 医学部, 研究医員 (80826884)

Project Period (FY) 2020-04-01 – 2024-03-31
KeywordsPBRM1 / 腎細胞癌 / pT3a / 再発 / 腎部分切除術
Outline of Annual Research Achievements

腎細胞がんの術後再発を予測する研究を継続中。
PBRMの抗体を購入し、引き続き、免疫染色や遺伝子学的な評価を行なっている。

またcT1の腎細胞がんに対しては、腎部分切除術が標準治療となっており、ロボット支援下腎部分切除術後の腎機能の評価について検討を行い、アメリカ泌尿器科学会AUAにて報告を行なった。
同内容で論文を作成し、Sci.Repに投稿した。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

研究成果を発表しながら、論文投稿を行なっている。

Strategy for Future Research Activity

PBRM1の発現をタンパクレベルだけでなく、RNAレベルでも評価するように模索している。

Causes of Carryover

RNAの研究が行えておらず、次年度に行い、研究資金を使用予定。
残額が余ったため次への繰越として使用。

  • Research Products

    (7 results)

All 2022 2021

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] PBRM1 Immunohistochemical Expression Profile Correlates with Histomorphological Features and Endothelial Expression of Tumor Vasculature for Clear Cell Renal Cell Carcinoma2022

    • Author(s)
      Saiga Kazuho、Ohe Chisato、Yoshida Takashi、Ohsugi Haruyuki、Ikeda Junichi、Atsumi Naho、Noda Yuri、Yasukochi Yoshiki、Higasa Koichiro、Taniguchi Hisanori、Kinoshita Hidefumi、Tsuta Koji
    • Journal Title

      Cancers

      Volume: 14 Pages: 1062~1062

    • DOI

      10.3390/cancers14041062

    • Peer Reviewed / Open Access
  • [Journal Article] Histologic-Based Tumor-Associated Immune Cells Status in Clear Cell Renal Cell Carcinoma Correlates with Gene Signatures Related to Cancer Immunity and Clinical Outcomes2022

    • Author(s)
      Ohe Chisato、Yoshida Takashi、Ikeda Junichi、Tsuzuki Toyonori、Ohashi Riuko、Ohsugi Haruyuki、Atsumi Naho、Yamaka Ryosuke、Saito Ryoichi、Yasukochi Yoshiki、Higasa Koichiro、Kinoshita Hidefumi、Tsuta Koji
    • Journal Title

      Biomedicines

      Volume: 10 Pages: 323~323

    • DOI

      10.3390/biomedicines10020323

    • Peer Reviewed / Open Access
  • [Journal Article] Integration of <scp>NRP1</scp> , <scp>RGS5,</scp> and <scp>FOXM1</scp> expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma2021

    • Author(s)
      Yoshida Takashi、Ohe Chisato、Ikeda Junichi、Atsumi Naho、Saito Ryoichi、Taniguchi Hisanori、Ohsugi Haruyuki、Sugi Motohiko、Tsuta Koji、Matsuda Tadashi、Kinoshita Hidefumi
    • Journal Title

      The Journal of Pathology: Clinical Research

      Volume: 7 Pages: 590~603

    • DOI

      10.1002/cjp2.232

    • Peer Reviewed / Open Access
  • [Journal Article] Predictors of postoperative recurrence in patients with non‐metastatic pT3a renal cell carcinoma2021

    • Author(s)
      Ohsugi Haruyuki、Ohe Chisato、Yoshida Takashi、Ikeda Junichi、Sugi Motohiko、Kinoshita Hidefumi、Matsuda Tadashi
    • Journal Title

      International Journal of Urology

      Volume: 28 Pages: 1060~1066

    • DOI

      10.1111/iju.14648

    • Peer Reviewed
  • [Journal Article] Tumor volume and tumor crossing of the axial renal midline predict renal function after robotic partial nephrectomy2021

    • Author(s)
      Ohsugi Haruyuki、Akiyama Kyojiro、Taniguchi Hisanori、Yanishi Masaaki、Sugi Motohiko、Matsuda Tadashi、Kinoshita Hidefumi
    • Journal Title

      Scientific Reports

      Volume: 11 Pages: 22526

    • DOI

      10.1038/s41598-021-01539-1

    • Peer Reviewed / Open Access
  • [Journal Article] Development and validation of a vascularity-based architectural classification for clear cell renal cell carcinoma: correlation with conventional pathological prognostic factors, gene expression patterns, and clinical outcomes2021

    • Author(s)
      Ohe Chisato、Yoshida Takashi、Amin Mahul B.、Atsumi Naho、Ikeda Junichi、Saiga Kazuho、Noda Yuri、Yasukochi Yoshiki、Ohashi Riuko、Ohsugi Haruyuki、Higasa Koichiro、Kinoshita Hidefumi、Tsuta Koji
    • Journal Title

      Modern Pathology

      Volume: Online ahead of print. Pages: Online ahead

    • DOI

      10.1038/s41379-021-00982-9

    • Peer Reviewed / Open Access
  • [Presentation] Accurate calculation of tumor volume and tumor crossing of the axial renal midline are preoperative predictors of reduced estimated glomerular filtration rate after robotic partial nephrectomy2021

    • Author(s)
      Haruyuki Ohsugi
    • Organizer
      米国泌尿器科学会
    • Int'l Joint Research

URL: 

Published: 2022-12-28  

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