Objective pain assessment of critical limb ischemia based on physiological indicators of the sympathetic nervous system

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K16487
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 51030:Pathophysiologic neuroscience-related
• Research Institution: University of Fukui
• Principal Investigator: Miyamae Makoto 福井大学, 学術研究院医学系部門(附属病院部), 医員 (80829060)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 下肢虚血 / 痛み / 交感神経反応 / 脈拍数 / 脈波振幅 / スキンコンダクタンス反応

Outline of Final Research Achievements

Sympathetic responses were verified in patients with leg ischemia by inflicting either heat-stimulated pain or pain of ischemia with a tourniquet. Pulse rate, pulse wave amplitude, and skin conductance response were used as sympathetic responses. Measurements were taken at the upper extremity, the non-ischemic site, and at the lower extremity, the ischemic site. The results showed that the responses differed depending on the pain stimulus. There were differences in pulse rate, pulse wave amplitude, and skin conductance response. There were differences in response between the non-ischemic upper extremity and the ischemic lower extremity.

Free Research Field

疼痛学、形成外科学

Academic Significance and Societal Importance of the Research Achievements

下肢虚血患者において、痛み刺激に対する違い、脈拍数、脈波振幅、スキンコンダクタンス反応についての違い、非虚血部位と虚血部位での違いで、交感神経反応の違いが生じること、脈波振幅においては虚血の痛みでは通常の痛み刺激による反応とは異なる反応をすることを示したことが、学術的意義である。この知見を活用して虚血と痛みと交感神経による悪循環を断ち切り診断と治療につなげて重症下肢虚血患者を痛みから救済することが、社会的意義である。