2021 Fiscal Year Final Research Report
Analysis of regulatory mechanisms of neural circuit repair by astrocyte
| Project/Area Number |
20K16496
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 51030:Pathophysiologic neuroscience-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | アストロサイト / 神経回路修復 |
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| Outline of Final Research Achievements |
After central nervous system injury, neural function is partially recovered by formation of compensatory neural circuit in mammals. The ability to form compensatory neural circuit is higher in neonate compared to adult. We previously found that astrocyte-related genes are differentially expressed between neonatal mice and adult mice after corticospinal tract injury by pyramidotomy. Here we investigated relationship between astrocyte and neural circuit repair focusing on analysis of candidate we found in the previous study. We created monoclonal antibodies against the candidate. By combining analyses using the antibodies, knock out mice we created, and dataset downloaded from database, the candidate is suggested to be useful as a novel unique astrocytic marker, which might be related to neural circuit repair.
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| Free Research Field |
神経病態科学
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| Academic Significance and Societal Importance of the Research Achievements |
アストロサイトと神経回路可塑性の関係は、視覚野の発生の研究等で近年着目されており、特異的なマーカー等、より詳細な解析を進めるために必要な基盤の開発が求められている。本研究では、候補遺伝子が神経回路可塑性に関与するアストロサイトのマーカーとなり得ることを発見し、解析に重要なツールを開発した。本研究で開発したツールはアストロサイトと神経回路可塑性の関係を解明するためのブレークスルーにつながる可能性がある。また、本研究を基盤としてアストロサイトと神経回路修復の関係の研究が進めば、将来的に、中枢神経系損傷の新規治療法開発につながる可能性がある。
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