2023 Fiscal Year Final Research Report
Elucidation of changes in macrophage function during chronic granulation formation in pulmonary MAC disease.
| Project/Area Number |
20K16527
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52010:General internal medicine-related
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| Research Institution | Kagoshima University |
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Principal Investigator |
Koriyama Toyoyasu 鹿児島大学, 医歯学域鹿児島大学病院, 臨床検査技師 (60723616)
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| Project Period (FY) |
2020-02-01 – 2024-03-31
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| Keywords | M. avium complex / MATR-VNTR / マイクロRNA / RICTOR |
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| Outline of Final Research Achievements |
In this study, MATR-VNTR analysis was performed using clinical strains isolated at the Clinical Laboratory of Kagoshima University Hospital. Polymorphism analysis was performed by PCR amplification of 15 MATR-VNTR regions.The isolated strains showed identical clones depending on the material type, which was confirmed to be very useful in identifying the route of infection in clinical site.
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| Free Research Field |
感染症学
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| Academic Significance and Societal Importance of the Research Achievements |
難治性慢性呼吸器疾患である肺 MAC (M. avium complex) 症は、世界中で患者数の増加傾向にある。本研究は、当院で2017年1月から同年5月の間に臨床検体より分離されたM. aviumを用いて、MATR-VNTR解析をおこった。解析の結果、同一クローンを示しており、感染ルートの知見のみならず病原性の高い株やポリクローナル感染の有無を評価できる。さらには治療開始の評価だけではなく、治療薬選択への応用が期待される。
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