Importance of abdominal organ congestion and hypoperfusion in patients with heart failure, and association with hepatkine

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K16529
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Fukushima Medical University
• Principal Investigator: Ichijo Yasuhiro 福島県立医科大学, 医学部, 病院助手 (00836041)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 心不全 / 多臓器連関 / 腹部超音波検査 / ヘパトカイン

Outline of Final Research Achievements

We investigated a method for evaluating congestion and hypoperfusion of abdominal organs in heart failure patients, compared to control population, using abdominal ultrasonography. In addition, liver-derived proteins selenoprotein-P (Sep-P) and fetuin-A were measured and evaluated for their association with hemodynamics.
Serum Sep-P / fetuin-A was significantly higher / lower in the heart failure group than in the control group. Furthermore, Sep-P / fetuin-A was higher / lower in the hepatic hypoperfusion group regardless of hepatic congestion. Heart failure re-exacerbation events increased in the Sep-P high-value group and in the fetuin-A low-value group, compared to the Sep-P low-value group and the fetuin-A high-value group.

Free Research Field

医学

Academic Significance and Societal Importance of the Research Achievements

心不全は心臓のポンプ機能低下により全身臓器のうっ血と低灌流を来たし、多臓器不全は心不全の不良な予後と関連している。しかし、腹部臓器の結構動態を評価する非侵襲的手法は確立されていない。また肝臓由来液性因子であるヘパトカインが恒常性維持に重要な役割を果たすことが分かってきたが、肝臓のうっ血や低灌流によるヘパトカイン分泌異常などの詳細は検討されていない。
本研究では腹部超音波検査による非侵襲的な腹部臓器の血行動態評価法の有効性が示唆された。また既知のヘパトカインSelenoprotein-P/fetuin-Aの、肝血行動態との関連、および心不全・多臓器連関のバイオマーカーとしての有益性が示唆された。