Establishment of precision medicine for insulin resistance targeting selective SNPs related to insulin resistance and secretion.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16551
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Ehime University
• Principal Investigator: Takakado Misaki 愛媛大学, 医学部附属病院, 助教 (30838032)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: インスリン抵抗性 / インスリン分泌 / 動脈硬化 / 遺伝子 / SNP

Outline of Final Research Achievements

To investigate the influence of Single nucleotide polymorphisms (SNPs) on the progression of glucose intolerance, we analyzed 2400 general Japanese population in the Toon Genome study. We analyzed the risk genotypes of SNPs including resistin which is reported to be associated with type 2 diabetes. We showed that 1-hour plasma glucose levels during a 75-g oral glucose tolerance test are potential predictors of developing glucose intolerance. Risk alleles of CDKAL1 gene polymorphism were associated with aggravation of 1-hour plasma glucose levels. We also found that carotid artery unstable plaque was associated with high resistin levels.

Free Research Field

糖尿病学・臨床検査医学

Academic Significance and Societal Importance of the Research Achievements

当研究室では、レジスチンSNP-420のG/G遺伝子型を有すると、C/C型と比べ、2型糖尿病のリスクが約1.8倍になることを報告している。本研究では、レジスチンSNPおよびCDKAL1と表現型を統合し新たな糖代謝異常分類法を確立し、動脈硬化および疾患発症との関連を明らかにした。将来の糖尿病発症、動脈硬化性疾患との関連の強いサブタイプを明らかにすることで、SNPをマーカーとしたインスリン抵抗性関連疾患および動脈硬化症の個別化予防・治療への発展が期待できる。