Clinical significance of S100 proteins in connective tissue diseases associated with interstitial pneumonia

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K16564
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Osaka Medical and Pharmaceutical University
• Principal Investigator: Hiramatsu Yuri 大阪医科薬科大学, 医学部, 助教 (70850072)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: rheumatic disease / interstitial pneumonia / S100 protein / calprotectin

Outline of Final Research Achievements

S100A8/A9 (calprotectin) is associated with the fibrosis and inflammation in lung. The aim of this study is to reveal the role of serum S100A8/A9 proteins in connective tissue diseases associated with interstitial pneumonia (CTD-IP). Serum levels of S100A8, S100A9, and calprotectin in patients with CTD were higher than those in controls. Calprotectin was increased in microscopic polyangiitis (MPA)-IP and rheumatoid arthritis (RA)-IP. S100A8 was elevated in MPA-IP, systemic sclerosis-IP, and RA-IP. S100A9 was increased in MPA-IP. There were no significant differences in S100A8/A9 proteins between MPA with and without IP and no correlation between serum levels of S100A8/A9 proteins and KL-6. However, there were differences in S100A8/A9 proteins between other CTD with and without IP. S100A8/A9 proteins may be related to the pathogenesis of CTD-IP. Further studies are needed to show the relation between S100A8/A9 proteins and CTD-IP.

Free Research Field

Rheumatology

Academic Significance and Societal Importance of the Research Achievements

膠原病に伴う間質性肺炎（CTD-IP）においてS100A8/A9タンパク質血中濃度が高値であり、疾患、特に顕微鏡的多発血管炎と関節リウマチおよびIPとの関連が示唆された。これまでにS100A8/A9タンパク質は肺の炎症のみならず線維化に関与することが報告されている。本研究の結果から、S100A8/A9タンパク質がCTD-IPのバイオマーカーのみならず新たな治療標的となる可能性が示唆された。