2023 Fiscal Year Annual Research Report
Cerebral microangiopathy: To clarify the pathologic basis and pathomechanism
| Project/Area Number |
20K16595
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| Research Institution | Niigata University |
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Principal Investigator |
齋藤 理恵 新潟大学, 脳研究所, 助教 (80829078)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 3D neuropathology / CADASIL / HTRA1-SVD / CAA / Aged brain / Small vessel disease |
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| Outline of Annual Research Achievements |
脳小血管病のSMA脱落の脳内の病変の進展様式について，CADASILでは白質，HTRA1-SVDでは脳表の太い細動脈，CAAでは脳表から広がることを明らかにした．さらにCAAでは脳内血管網におけるAβの沈着様式を可視化し，定量化することに成功した．
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[Journal Article] Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans2024
Author(s)
Joe A. Holley, Shoichiro Ando, Samuel D. Chauvin, Atsushi Sugie, Rie Saito, Yuya Hatano, Sho Kitahara, Shin Koide, Akiyoshi Kakita, Osamu Onodera, Taisuke Kato, Jonathan J. Miner
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Journal Title
Nature Communications
Volume: -
Pages: -
Peer Reviewed / Open Access / Int'l Joint Research
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