2023 Fiscal Year Final Research Report
Cerebral microangiopathy: To clarify the pathologic basis and pathomechanism
| Project/Area Number |
20K16595
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52020:Neurology-related
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| Research Institution | Niigata University |
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Principal Investigator |
Saito Rie 新潟大学, 脳研究所, 助教 (80829078)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 3D neuropathology / CADASIL / HTRA1-SVD / CAA / Smooth muscle cells |
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| Outline of Final Research Achievements |
We have clarified the progression patterns of SMA loss in cerebral small vessel disease: in CADASIL, lesions predominantly affect the white matter; in HTRA1-SVD, they target the large arterioles on the brain surface; and in CAA, they spread from the brain surface.
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| Free Research Field |
神経病理学
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| Academic Significance and Societal Importance of the Research Achievements |
脳小血管病の代表的な疾患について，脳内の小動脈の変性パターンを明らかにすることができた．この知見は，今後大脳の白質病変の進展様式を理解し，疾患ごとの血管網の部位特異的な脆弱性をもたらす病態研究をする上で重要な情報を提供する．
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