Does residual physiological and cognitive hyperarousal predict relapse of major depressive disorder?

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16615
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Akita University
• Principal Investigator: Takeshima Masahiro 秋田大学, 医学系研究科, 講師 (60778736)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: Hyperarousal / Depression

Outline of Final Research Achievements

The aim of this study was to explore whether cognitive hyperarousal predicts relapse of depression. Patients whose major depressive disorder was in remission after inpatient treatment were evaluated at discharge using a hyperarousal scale. Then, whether cognitive hyperarousal predicted recurrence of depression within one year of discharge was investigated. However, there was no difference in recurrence rates between the high and low hyperarousal groups, and the study failed to demonstrate that the cognitive hyperarousal scale is a marker of depression recurrence.

Free Research Field

Psychiatry

Academic Significance and Societal Importance of the Research Achievements

本研究は認知的過覚醒尺度がうつ病再発マーカーであることを示すことはできなかったが、本研究はサンプル数の小さい探索的試験であるため、今後更なる研究が必要である。