Examination of the usefulness of near-infrared spectroscopy in predicting treatment responsiveness for tic-related obsessive-compulsive disorder.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K16632
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Hyogo Medical University
• Principal Investigator: Mukai Keiichiro 兵庫医科大学, 医学部, 助教 (70739218)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 強迫症 / 近赤外線スペクトロスコピー

Outline of Final Research Achievements

The main findings of this study was published in Psychiatry and Clinical Neuroscience, indicating specific hemodynamic changes in tic-related obsessive-compulsive disorder . 29 obsessive-compulsive patients were divided into two groups (TD(+) and TD(-)) according to the presence of a history of tic disorder, and data comparing healthy subjects were reported (Mukai, et al. 2020). The integration of hemodynamic changes in the dorsolateral prefrontal cortex during ToL in the TD(+) group had a direct effect on the severity of compulsion, while in the TD(-) group the severity of obsession was significantly modified by activations in the DLPFC.

Free Research Field

強迫症

Academic Significance and Societal Importance of the Research Achievements

チック関連性強迫症は、チック症の既往のない強迫症と治療法に相違がある。本課題により、チック関連性強迫症の診断法としてNIRSが有用である可能性が示唆された。本課題で着手した臨床レベルの有用性実証研究を継続・発展させることにより、強迫症の診断および治療選択におけるNIRSの補助的診断ツールとして開発が可能となる。これは、最適な治療戦略の選択の一助となり得る簡便で侵襲性の低い診断法が確立され、治療効果の効率的な享受と有害事象の最小化につながる。