2022 Fiscal Year Final Research Report
Studies of quantitative analysis of cardiac amyloidosis using SPECT/CT with Tc-99m pyrophosphate
| Project/Area Number |
20K16695
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 心臓アミロイドーシス / ピロリン酸心筋シンチグラフィ |
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| Outline of Final Research Achievements |
The purpose of our study was to assess quantitative analysis of cardiac amyloidosis using SPECT/CT (single photon emission computed tomography/computed tomography) with Tc-99m pyrophosphate (PYP).
Myocardial Tc-99m PYP accumulation was quantified, and some standardized uptake values (SUVs) were calculated for comparisons with visual scoring system (VSp) and heart-to-contralateral (H/CL) ratio. The correlation between cardiac accumulation and histopathological amyloid infiltration in biopsied myocardial specimens was investigated.
In our study, SUVs were not significantly correlated with the cardiac amyloid deposition grade of biopsy samples, possibly due to the heterogeneous deposition of amyloid. Meanwhile, SUV range tended to be broader than H/CL range in VSp-positive patients, suggesting that SUVs could distinguish amyloid burden more clearly. Our results suggest that the quantitative analysis of SPECT/CT with Tc-99m PYP may potentially evaluate overall cardiac amyloid burden.
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| Free Research Field |
放射線科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究において、心臓アミロイドーシスにおけるピロリン酸心筋シンチグラムによる定量的評価法が、従来法の視覚的評価法より心臓全体のアミロイド沈着量をより明瞭に識別できる可能性が示された。
今後、心筋組織生検より侵襲性の低い本評価法を用いることにより、患者への負担を軽減しながら、本疾患の鑑別診断や治療効果判定が可能になると考えられる。また、本評価法を心臓アミロイドーシスの診断基準に組み込むことにより、新たな診断アルゴリズムの構築に寄与しうると考えられる。
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