Development of standardization method of tau-PET imaging in Alzheimer's disease

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16747
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kitasato University (2021-2022); Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2020)
• Principal Investigator: Wagatsuma Kei 北里大学, 医療衛生学部, 講師 (40738283)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 認知症 / アルツハイマー病 / PET / 定量評価

Outline of Final Research Achievements

We have developed a tau PET-specific phantom for determining image reconstruction conditions for tau PET imaging. The tau PET phantom was easier to prepare than the phantoms used in conventional brain PET, and it was possible to evaluate the image quality (contrast, noise) and quantitativity of brain PET images in a single PET imaging session. The use of a dedicated phantom for tau PET allows optimization of image reconstruction conditions for tau PET and contributes to standardization.

Free Research Field

核医学

Academic Significance and Societal Importance of the Research Achievements

タウPETはアルツハイマー病の重症度評価、治療方針の決定、治療効果判定などの利用に期待されている。これらの目的のためにタウPETを利用するならば、タウPETは縦断的、横断的に利用される事となり、タウPET画像は定性的・定量的に再現性の良い画像が要求される。タウPET専用ファントムでタウPETの画像再構成条件を最適化することができれば、タウPETイメージングの標準化に大きく寄与すると考える。