Development and clinical application of minimally invasive myocardial CT perfusion imaging for optimal myocardial ischemia assessment

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16760
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Ehime University
• Principal Investigator: Tanabe Yuki 愛媛大学, 医学部附属病院, 助教(病院教員) (70836189)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: myocardial perfusion

Outline of Final Research Achievements

In this study, we developed an optimized method for myocardial static computed tomography perfusion (CTP) imaging and a new quantitative evaluation technique (MPR; Myocardial Perfusion Ratio to the Aorta), and evaluated the feasibility in the diagnosis of ischemic heart disease. This study included patients suspected of ischemic heart disease who underwent both myocardial CTP scan and coronary angiography (CAG). By using a "Boost scan" in the dynamic scan, both static and dynamic CTP data were collected in a single CTP scan. In the diagnosis of ischemic heart disease, there was no significant difference between dynamic and static CTP imaging. Regarding the radiation exposure, it was estimated that static scans resulted in significantly lower radiation exposure than dynamic scans.

Free Research Field

心臓CT

Academic Significance and Societal Importance of the Research Achievements

本研究では、心筋Static CTPにおいては従来の定性評価に加え、MPRを用いた定量評価を併用することで診断能が向上し、心筋Dynamic CTPより低被ばく、かつ同等の精度で虚血性心疾患の評価ができる可能性が示唆された。Static CTPはDynamic CTPと比較してCT装置に関する制限が少なく、より低侵襲に心筋虚血評価を行えるということは、心筋CTP検査の臨床普及および患者負担の軽減に寄与するものと思われる。