2023 Fiscal Year Final Research Report
Development of a new treatment for deep abscesses using Non-thermal ablation
| Project/Area Number |
20K16788
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Kindai University (2023)
Kobe University (2020-2022) |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | IRE / 深部膿瘍 |
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| Outline of Final Research Achievements |
This study investigates the efficacy of Irreversible electroporation (IRE), a technique in which an electrode needle is percutaneously inserted and energized, for the treatment of deep abscesses. IRE has been applied to locally advanced pancreatic cancer and hepatocellular carcinoma. In the future, it is expected to be applied to other malignant tumors. In this study, mice with deep-seated abscesses (liver abscesses) were used to investigate the aforementioned usefulness. Throughout the research period, we published one original paper in English, two review articles, one review article in Japanese, and two conference presentations. We have also been involved in the writing of the book about CT scan.
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| Free Research Field |
放射線医学
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| Academic Significance and Societal Importance of the Research Achievements |
Irreversible electroporation(IRE)は これまで局所進行膵癌や肝細胞癌で治療応用され、今後はその他の悪性腫瘍について応用が期待されている。肺の難治性膿瘍に対しラジオ波焼却療法が報告されており、本研究ではマウスを用いた深部膿瘍(肝膿瘍)について検討した。腹部の難治性膿瘍の主治療は抗菌薬とドレナージであるが、焼却療法が臨床応用されることで、患者のQOLの向上や治療・入院期間の短縮に繋がることが今後期待される。
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