Development of a novel IVR therapy using lenvatinib-loading beads for advanced hepatocellular carcinoma

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K16800
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Nara Medical University
• Principal Investigator: Sato Takeshi 奈良県立医科大学, 医学部, 助教 (80773788)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 画像下治療 / 肝動脈化学塞栓療法 / 肝細胞癌 / 薬剤溶出性球状塞栓物質 / 分子標的薬

Outline of Final Research Achievements

In an in vivo experiment, the method for creating liver tumor models in rats and rabbits and the catheter technique for performing selective transarterial chemoembolization (TACE) were established.
In an ex vivo experiment, the strategy was changed to use a different type of drug-eluting beads loaded with an anti-tumor drug through ionic bonding.

Free Research Field

ライフサイエンス

Academic Significance and Societal Importance of the Research Achievements

動物モデル作成とTACE手技の確立により、前臨床研究を行うことができるようになったことに学術的意義がある。
肝細胞癌患者に対する治療選択肢を広げ、治療成績の向上につながる可能性があることに社会的意義がある。