Analysis of a mouse model of generalized lymphatic anomaly

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K16912
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Tohoku University
• Principal Investigator: Nozawa Akifumi 東北大学, 大学病院, 医員 (20772106)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: リンパ管疾患

Outline of Final Research Achievements

Generalized lymphatic anomaly previously known as diffuse systemic lymphangiomatosis is a rare multisystem congenital disease arising from the lymphatic system, and it is characterized by abnormal proliferation of the lymphatic channels in osseous and extraosseous tissues. We expressed an active form of NRAS (p.Q61R) in murine lymphatics (iLECNras mice). We found that iLECNras mice developed dilated lymphatic vessels, which is a hallmark of generalized lymphatic anomaly.

Free Research Field

小児科

Academic Significance and Societal Importance of the Research Achievements

作製したリンパ管腫症モデルマウスを解析することにより、リンパ管腫症の病態解明に繋がり、リンパ管腫症の病変を特異的に抑制する治療薬の開発にも繋げられることが可能となる。また将来的には、リンパ管腫症の難治症例の治癒率やQOL向上、医療費削減などの社会貢献に繋げることができる。