2022 Fiscal Year Final Research Report
Investigation of the efficacy of continuous CRH administration given to the artificial uterus system.
| Project/Area Number |
20K16913
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52050:Embryonic medicine and pediatrics-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 人工子宮システム / CRH / ACTH / コルチゾール / 早産児 |
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| Outline of Final Research Achievements |
We administered CRH (corticotropin-releasing hormone), which is normally secreted by the placenta, continuously under the control of an artificial uterine system, and verified that the development of the fetal hypothalamus-pituitary-adrenal system was the same as that of infants born in the uterus. The results of this study were as follows. Some of the fetuses were able to grow with continuous administration of CRH, but additional cortisol supplementation was necessary to maintain circulation. Moreover, a postnatal CRH challenge test showed that these pups were not equivalent to those grown in utero. In addition to continuous CRH administration, the placenta must be supplemented with additional endocrine functions necessary for growth to minimize complications associated with long-term survival.
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| Free Research Field |
新生児学分野
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により人工子宮システム管理下において本来の子宮内で生育した仔と同等の内分泌学的機能を獲得するためには，仔のストレス応じた適切なコルチゾール量の制御とCRH持続投与の他に胎盤が持つ内分泌機能を付与することが必要である．今後人工子宮システムの発展に伴い長期生存が期待されるが，本来の胎盤が持つ未解明な機能について明らかにすることで合併症を最小限し現在の新生児医療の代替療法となることを期待する．
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