Elucidation of NIRS-Internal Cerebral Vein Fluctuation Association for Prevention of Intraventricular Hemorrhage

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16930
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Sapporo Medical University
• Principal Investigator: Fusagawa Shintaro 札幌医科大学, 医学部, 研究員 (20866131)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: NIRS / INVOS / rScO2 / 内大脳静脈 / 揺らぎ / 脳室内出血 / IVH / 超低出生体重児

Outline of Final Research Achievements

Intraventricular hemorrhage (IVH) is a serious complication in neonates; however, monitoring methods for the prevention of IVH have not yet been established. In this study, we investigated the association between blood flow waveforms of the internal cerebral vein (ICV) and regional cerebral oxygen saturation (rScO2).
The rScO2 was monitored from NICU admission to 72 h after birth in 10 patients weighing less than 1000 g at gestation from 24 to 30 weeks. rScO2 was compared between the low-grade group (seven patients) and the high-grade group (three patients) of ICV fluctuation, but no significant difference in the background was found. rScO2 peaked at approximately 24-48 hours, with no significant difference between the two groups. This study did not reveal any relationship between ICV fluctuations and rScO2.

Free Research Field

新生児　脳循環

Academic Significance and Societal Importance of the Research Achievements

本調査では、内大脳静脈の揺らぎと脳の局所酸素飽和度との関連性を明らかにすることはできなかった。新型コロナウイルスの影響等により、患者数や病床数の制限を受けたことで、予定通りの解析ができなかったことが原因の一つと考えられる。内大脳静脈の揺らぎや、脳の局所的酸素飽和度といった分野には、未解明の要素が依然として数多く存在している。これを探求して理解を深めれば、適切な循環管理で脳室内出血の発症リスクを下げることが可能になると考えられ、社会的にも大きな意義があると言える。本研究がこの分野における新たな知見の契機となり、更なる研究が推進されることに期待したい。