Establishment of a prediction system of relapse in Kawasaki disease based on cytokine response.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16937
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: St. Luke's International University
• Principal Investigator: ONO Rintaro 聖路加国際大学, 聖路加国際病院, 医員 (80841197)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: サイトカイン / 川崎病 / 免疫

Outline of Final Research Achievements

Cytokine profiling was performed on pre- and post-treatment samples in 63 patients with Kawasaki disease. In some cases, immune-profiling was also performed using mass cytometry. For comparison, these analyses were also performed in hypercytokine-associated other pediatric diseases such as hemophagocytic lymphohistiocytosis. This study revealed that even patients with Kawasaki disease exhibit different cytokine patterns and immune cell subset patterns. Further analysis is warranted in larger cohort of Kawasaki disease and other hypercytokine diseases.

Free Research Field

小児免疫、自己炎症

Academic Significance and Societal Importance of the Research Achievements

川崎病患者において、共通して上昇するサイトカインよび患者、治療経過ごとに異なるサイトカインのパターンを明らかにした。本研究の成果を応用し、将来的にサイトカイン解析から再発・難治例を予測し、個々の患者にとって最適と考えられる治療を提案できる可能性がある。