Analysis of microRNA in gastric cancer with peritoneal dissemination

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K16966
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Iwai Naoto 京都府立医科大学, 医学(系)研究科(研究院), 研修員 (00823270)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 胃癌 / 腹膜播種 / マイクロRNA

Outline of Final Research Achievements

Paired samples of cancerous and non-cancerous tissues were obtained by biopsy using esophagogastroduodenoscopy regarding six cases of advanced gastric cancer with peritoneal dissemination. A genome-wide miRNA gene expression analysis was performed to identify miRNAs associated with development of peritoneal dissemination in gastric cancer. We found that 7 miRNAs are upregulated in cancerous tissues and 16 miRNAs are downregulated in cancerous tissues.

Free Research Field

消化器内科学

Academic Significance and Societal Importance of the Research Achievements

胃癌腹膜播種の病態解明は、がん患者の予後改善のために改善すべき課題であり、本研究は臨床検体を用いて、胃癌腹膜播種の診断バイマーカーとなりうるマイクロRNAの同定を行った。今後、胃癌腹膜播種形成におけるマイクロRNAを介した分子機構を解明することで、胃癌腹膜播種に対しての新規治療法の確立が期待される。